Sam Mazin, Founder and CEO of RefleXion Medical, speaks with Colin Cahill at Venrock about managing a big project with a lean budget, raising money, and communicating an evolving and complex vision. They explore the evolution of RefleXion’s addressable market as clinical data showed better results than the standard of care, and what that means for some cancer patients. Sam and Colin also talked about learning to manage “on the job” and how you manage people who have more experience. Sam’s research as a postdoc at Stanford led to the idea of combining radiotherapy with PET imaging, and RefleXion Medical was born.